Neuroscience of Asthma
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BM DPhil FRCA
Senior Clinical Research Fellow
- Consultant Anaesthetist and Associate Professor
FMRI of respiratory control
Disorders of respiratory control are implicated in a wide spectrum of disease including: chronic obstructive airways disease, asthma, neurodegenerative diseases, sleep apnoea and sudden infant death syndrome. In particular, chronic obstructive airways disease causes distressing shortness of breath, and is one of the major debilitating diseases in the world. Drugs used for pain relief, such as morphine, have potentially fatal side effects due to their effects upon respiratory centres in the brain. My research centres upon investigating mechanisms of respiratory control, and the processes underlying breathlessness, using non-invasive magnetic resonance imaging techniques.
Imaging brain perfusion changes following aneurysmal subarachnoid haemorrhage
Delayed cerebral ischaemia is a major cause of morbidity and mortality following subarachnoid haemorrhage. Successful targeted treatment requires an accurate, non-invasive, and reproducible measure of cerebral perfusion. Current techniques are limited in their clinical application as they only image larger arteries and require the use of contrast agents and/or ionising radiation. We are trialing novel magnetic resonance imaging techniques that do not require exogenous contrast agents that demonstrate quantitative measures of cerebral perfusion at the tissue level. This would potentially facilitate the early and targeted use of vasospasm therapies and so reduce long-term morbidity and mortality.
The effect of d-cycloserine on brain processing of breathlessness over pulmonary rehabilitation: an experimental medicine study.
Finnegan SL. et al, (2023), ERJ Open Res, 9
Brain activity measured by functional brain imaging predicts breathlessness improvement during pulmonary rehabilitation.
Finnegan SL. et al, (2022), Thorax
Beneficial Effect of Sodium Nitrite on EEG Ischaemic Markers in Patients with Subarachnoid Haemorrhage.
Luettich A. et al, (2022), Transl Stroke Res, 13, 265 - 275
Perceptual and Ventilatory Responses to Hypercapnia in Athletes and Sedentary Individuals
Harrison OK. et al, (2022), Frontiers in Physiology, 13
Baseline Psychological Traits Contribute to Lake Louise Acute Mountain Sickness Score at High Altitude.
Talks BJ. et al, (2022), High Alt Med Biol, 23, 69 - 77