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NeuroSCOPE Lab

Mapping circuits, modeling motivation, guiding precision interventions, digital phenotyping and biofeedback

The NeuroSCOPE lab investigates the brain circuits underlying motivation and mood, with a particular focus on characterising depression. We are interested in combining multi-modal neuroscientific tools to not only deepen our understanding of the human brain but also to advance personalised mental healthcare. Using high-resolution 7T MRI, reinforcement learning paradigms, and digital phenotyping via EMAware technology, we aim to characterise motivation and its neural mechanisms. Through integrating neuroimaging with precision biofeedback interventions, we aim to map and modulate brain activity, implementing a rigorous and individualised approach to understanding and treating mood disorders. 

Our team

Latest publications

MOdulation-Guided ENcoding (MOGEN) Scheme for Vessel-Encoded Arterial Spin Labeling.

Journal article

Li H. et al, (2026), Magn Reson Med

Brain essay competition winner on artificial general intelligence.

Journal article

Husain M., (2026), Brain, 149

Understanding human metacontrol and its pathologies using deep neural networks.

Journal article

Sandbrink KJ. et al, (2026), Proc Natl Acad Sci U S A, 123

Key Readings

Digital measures of activity and motivation impact depression and anxiety in the real world

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Cross-species dissection of the modular role of the ventral tegmental area in depressive disorders

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Ventral tegmental area integrity measured with high-resolution 7-Tesla MRI relates to motivation across depression and anxiety diagnoses

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