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Since the advent of modern neuroimaging techniques, studies have been carried out to examine nociceptive processing within the human brain non-invasively. Combined with advances in immunohistochemistry, histology and genetics, we have been able to correlate more objective measures of nociceptive processing with the subjective experience that is pain. The result has produced a dramatic shift in our thinking about the neural circuitry involved in nociceptive processing, revealing that pain is much more than a submodality of the sense of touch.

Original publication




Journal article


Curr Opin Neurobiol

Publication Date





478 - 487


Afferent Pathways, Animals, Brain, Brain Mapping, Humans, Nociceptors, Pain