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"The effect of Baclofen on motor learning and brain chemistry" (Ethics ref: R55534/RE001)


We are looking for volunteers to participate in a study investigating how the drug Baclofen affects our brain and our ability to learn and remember new motor tasks. We would want you to be involved in the study on 2 days, each around a week apart. On each day of the study you would be asked to participate for the whole day, with one morning session (lasting around 4.5 hours), and one afternoon session (around 0.5 hours).

In the morning sessions you will take one dose of either Baclofen or placebo, perform a motor task, and we will examine changes in motor responses induced by transcranial magnetic stimulation (TMS). In the afternoon sessions your skill on the motor task will be re-tested.

We need right-handed volunteers between 18 and 35 years old, who do not play a musical instrument to a high level (e.g. to grade 6 or above and still taking part in regular practice). You must be in good health and without a history of epilepsy or any other disease affecting the brain or spinal cord.  If you are pregnant you should not volunteer.

Sessions will take place at the John Radcliffe or Warneford Hospital. You will be remunerated for you time.



Study Title: The effect of Baclofen on motor learning and brain chemistry

Study Ethics Ref: R55534/RE001

Study Researcher: Ainslie Johnstone (