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A list of key publications by the PAIN Group at FMRIB.




Bantick SJ, Wise RG, Ploghaus A, Clare S, Smith SM, Tracey I. Imaging how

attention modulates pain in humans using functional MRI. Brain. 2002 Feb;125(Pt

2):310-9. PubMed PMID: 11844731.


Berna C, Leknes S, Holmes EA, Edwards RR, Goodwin GM, Tracey I. Induction of

depressed mood disrupts emotion regulation neurocircuitry and enhances pain

unpleasantness. Biol Psychiatry. 2010 Jun 1;67(11):1083-90. doi:

10.1016/j.biopsych.2010.01.014. Epub 2010 Mar 29. PubMed PMID: 20303069.


Bingel U, Wanigasekera V, Wiech K, Ni Mhuircheartaigh R, Lee MC, Ploner M,

Tracey I. The effect of treatment expectation on drug efficacy: imaging the

analgesic benefit of the opioid remifentanil. Sci Transl Med. 2011 Feb

16;3(70):70ra14. doi: 10.1126/scitranslmed.3001244. PubMed PMID: 21325618.


Brodersen KH, Wiech K, Lomakina EI, Lin CS, Buhmann JM, Bingel U, Ploner M,

Stephan KE, Tracey I. Decoding the perception of pain from fMRI using

multivariate pattern analysis. Neuroimage. 2012 Nov 15;63(3):1162-70. doi:

10.1016/j.neuroimage.2012.08.035. Epub 2012 Aug 18. PubMed PMID: 22922369; PubMed

Central PMCID: PMC3532598.


Brooks JC, Kong Y, Lee MC, Warnaby CE, Wanigasekera V, Jenkinson M, Tracey I.

Stimulus site and modality dependence of functional activity within the human

spinal cord. J Neurosci. 2012 May 2;32(18):6231-9. doi:

10.1523/JNEUROSCI.2543-11.2012. PubMed PMID: 22553029.


Brooks JC, Zambreanu L, Godinez A, Craig AD, Tracey I. Somatotopic

organisation of the human insula to painful heat studied with high resolution

functional imaging. Neuroimage. 2005 Aug 1;27(1):201-9. PubMed PMID: 15921935.


Denk F, McMahon SB, Tracey I. Pain vulnerability: a neurobiological

perspective. Nat Neurosci. 2014 Feb;17(2):192-200. doi: 10.1038/nn.3628. Epub

2014 Jan 28. Review. PubMed PMID: 24473267.


Gwilym SE, Filippini N, Douaud G, Carr AJ, Tracey I. Thalamic atrophy

associated with painful osteoarthritis of the hip is reversible after

arthroplasty: a longitudinal voxel-based morphometric study. Arthritis Rheum.

2010 Oct;62(10):2930-40. doi: 10.1002/art.27585. PubMed PMID: 20518076.


Iannetti GD, Zambreanu L, Wise RG, Buchanan TJ, Huggins JP, Smart TS, Vennart

W, Tracey I. Pharmacological modulation of pain-related brain activity during

normal and central sensitization states in humans. Proc Natl Acad Sci U S A. 2005

Dec 13;102(50):18195-200. Epub 2005 Dec 5. PubMed PMID: 16330766; PubMed Central

PMCID: PMC1306794.


Kong Y, Eippert F, Beckmann CF, Andersson J, Finsterbusch J, Büchel C, Tracey

I, Brooks JC. Intrinsically organized resting state networks in the human spinal

cord. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):18067-72. doi:

10.1073/pnas.1414293111. Epub 2014 Dec 3. PubMed PMID: 25472845; PubMed Central

PMCID: PMC4273395.


Lee MC, Zambreanu L, Menon DK, Tracey I. Identifying brain activity

specifically related to the maintenance and perceptual consequence of central

sensitization in humans. J Neurosci. 2008 Nov 5;28(45):11642-9. doi:

10.1523/JNEUROSCI.2638-08.2008. PubMed PMID: 18987200.


Leknes S, Berna C, Lee MC, Snyder GD, Biele G, Tracey I. The importance of

context: when relative relief renders pain pleasant. Pain. 2013

Mar;154(3):402-10. doi: 10.1016/j.pain.2012.11.018. Epub 2012 Dec 13. PubMed

PMID: 23352758; PubMed Central PMCID: PMC3590449.


Makin TR, Scholz J, Filippini N, Henderson Slater D, Tracey I, Johansen-Berg

H. Phantom pain is associated with preserved structure and function in the former

hand area. Nat Commun. 2013;4:1570. doi: 10.1038/ncomms2571. PubMed PMID:

23463013; PubMed Central PMCID: PMC3615341.


Mezue M, Segerdahl AR, Okell TW, Chappell MA, Kelly ME, Tracey I. Optimization

and reliability of multiple postlabeling delay pseudo-continuous arterial spin

labeling during rest and stimulus-induced functional task activation. J Cereb

Blood Flow Metab. 2014 Dec;34(12):1919-27. doi: 10.1038/jcbfm.2014.163. Epub 2014

Oct 1. PubMed PMID: 25269517; PubMed Central PMCID: PMC4269746.


Mhuircheartaigh RN, Rosenorn-Lanng D, Wise R, Jbabdi S, Rogers R, Tracey I.

Cortical and subcortical connectivity changes during decreasing levels of

consciousness in humans: a functional magnetic resonance imaging study using

propofol. J Neurosci. 2010 Jul 7;30(27):9095-102. doi:

10.1523/JNEUROSCI.5516-09.2010. PubMed PMID: 20610743.


Ní Mhuircheartaigh R, Warnaby C, Rogers R, Jbabdi S, Tracey I. Slow-wave

activity saturation and thalamocortical isolation during propofol anesthesia in

humans. Sci Transl Med. 2013 Oct 23;5(208):208ra148. doi:

10.1126/scitranslmed.3006007. PubMed PMID: 24154602.


Ploghaus A, Narain C, Beckmann CF, Clare S, Bantick S, Wise R, Matthews PM,

Rawlins JN, Tracey I. Exacerbation of pain by anxiety is associated with activity

in a hippocampal network. J Neurosci. 2001 Dec 15;21(24):9896-903. PubMed PMID:



Ploghaus A, Tracey I, Clare S, Gati JS, Rawlins JN, Matthews PM. Learning

about pain: the neural substrate of the prediction error for aversive events.

Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9281-6. PubMed PMID: 10908676; PubMed

Central PMCID: PMC16859.


Ploghaus A, Tracey I, Gati JS, Clare S, Menon RS, Matthews PM, Rawlins JN.

Dissociating pain from its anticipation in the human brain. Science. 1999 Jun

18;284(5422):1979-81. PubMed PMID: 10373114.


Ploner M, Lee MC, Wiech K, Bingel U, Tracey I. Prestimulus functional

connectivity determines pain perception in humans. Proc Natl Acad Sci U S A. 2010

Jan 5;107(1):355-60. doi: 10.1073/pnas.0906186106. Epub 2009 Nov 30. PubMed PMID:

19948949; PubMed Central PMCID: PMC2806712.


Rogers R, Wise RG, Painter DJ, Longe SE, Tracey I. An investigation to

dissociate the analgesic and anesthetic properties of ketamine using functional

magnetic resonance imaging. Anesthesiology. 2004 Feb;100(2):292-301. PubMed PMID:



Tracey I. Getting the pain you expect: mechanisms of placebo, nocebo and

reappraisal effects in humans. Nat Med. 2010 Nov;16(11):1277-83. doi:

10.1038/nm.2229. Epub 2010 Oct 14. PubMed PMID: 20948533.


Tracey I, Ploghaus A, Gati JS, Clare S, Smith S, Menon RS, Matthews PM.

Imaging attentional modulation of pain in the periaqueductal gray in humans. J

Neurosci. 2002 Apr 1;22(7):2748-52. PubMed PMID: 11923440.


Wall and Melzack’s Textbook of Pain, 6th Edition (2013 in press). Editors: Stephen McMahon & Martin Koltzenburg & Irene Tracey & Dennis C. Turk


Wanigasekera V, Lee MC, Rogers R, Kong Y, Leknes S, Andersson J, Tracey I.

Baseline reward circuitry activity and trait reward responsiveness predict

expression of opioid analgesia in healthy subjects. Proc Natl Acad Sci U S A.

2012 Oct 23;109(43):17705-10. doi: 10.1073/pnas.1120201109. Epub 2012 Oct 8.

PubMed PMID: 23045652; PubMed Central PMCID: PMC3491480.


Wiech K, Lin CS, Brodersen KH, Bingel U, Ploner M, Tracey I. Anterior insula

integrates information about salience into perceptual decisions about pain. J

Neurosci. 2010 Dec 1;30(48):16324-31. doi: 10.1523/JNEUROSCI.2087-10.2010. PubMed

PMID: 21123578.


Wiech K, Jbabdi S, Lin CS, Andersson J, Tracey I. Differential structural and

resting state connectivity between insular subdivisions and other pain-related

brain regions. Pain. 2014 Oct;155(10):2047-55. doi: 10.1016/j.pain.2014.07.009.

Epub 2014 Jul 15. PubMed PMID: 25047781; PubMed Central PMCID: PMC4220010.


Wiech K, Vandekerckhove J, Zaman J, Tuerlinckx F, Vlaeyen JW, Tracey I.

Influence of prior information on pain involves biased perceptual

decision-making. Curr Biol. 2014 Aug 4;24(15):R679-81. doi:

10.1016/j.cub.2014.06.022. PubMed PMID: 25093555; PubMed Central PMCID:



Wise RG, Williams P, Tracey I. Using fMRI to quantify the time dependence of

remifentanil analgesia in the human brain. Neuropsychopharmacology. 2004

Mar;29(3):626-35. PubMed PMID: 14679387.


Zambreanu L, Wise RG, Brooks JC, Iannetti GD, Tracey I. A role for the

brainstem in central sensitisation in humans. Evidence from functional magnetic

resonance imaging. Pain. 2005 Apr;114(3):397-407. PubMed PMID: 15777865.