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Serotonin functions as an essential neuromodulator that serves a multitude of roles, most prominently balancing mood. Serotonergic challenge has been observed to reduce intrinsic functional connectivity in brain regions implicated in mood regulation. However, the full scope of serotonergic action on functional connectivity in the human brain has not been explored. Here, we show evidence that a single dose of a serotonin reuptake inhibitor dramatically alters functional connectivity throughout the whole brain in healthy subjects (n = 22). Our network-centrality analysis reveals a widespread decrease in connectivity in most cortical and subcortical areas. In the cerebellum and thalamus, however, we find localized increases. These rapid and brain-encompassing connectivity changes linked to acute serotonin transporter blockade suggest a key role for the serotonin transporter in the modulation of the functional macroscale connectome.

Original publication

DOI

10.1016/j.cub.2014.08.024

Type

Journal article

Journal

Curr Biol

Publication Date

06/10/2014

Volume

24

Pages

2314 - 2318

Keywords

Adult, Brain, Citalopram, Connectome, Cross-Over Studies, Double-Blind Method, Female, Humans, Male, Random Allocation, Serotonin, Serotonin Uptake Inhibitors, Young Adult