Integrating new memories into the hippocampal network activity space.
Gava GP., McHugh SB., Lefèvre L., Lopes-Dos-Santos V., Trouche S., El-Gaby M., Schultz SR., Dupret D.
By investigating the topology of neuronal co-activity, we found that mnemonic information spans multiple operational axes in the mouse hippocampus network. High-activity principal cells form the core of each memory along a first axis, segregating spatial contexts and novelty. Low-activity cells join co-activity motifs across behavioral events and enable their crosstalk along two other axes. This reveals an organizational principle for continuous integration and interaction of hippocampal memories.