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By investigating the topology of neuronal co-activity, we found that mnemonic information spans multiple operational axes in the mouse hippocampus network. High-activity principal cells form the core of each memory along a first axis, segregating spatial contexts and novelty. Low-activity cells join co-activity motifs across behavioral events and enable their crosstalk along two other axes. This reveals an organizational principle for continuous integration and interaction of hippocampal memories.

Original publication

DOI

10.1038/s41593-021-00804-w

Type

Journal article

Journal

Nat Neurosci

Publication Date

03/2021

Volume

24

Pages

326 - 330