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SummaryWe reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research shows there is an opportunity for brain-selective CCBs, which are better suited to psychiatric indications.Declaration of interestE.M.T. and P.J.H. hold an unrestricted educational grant from Johnson & Johnson to work on the molecular neurobiology of calcium channels.

Original publication




Journal article


Br J Psychiatry

Publication Date



1 - 4


Calcium channels, bipolar affective disorders, novel central nervous system drugs, psychiatry, therapy