Post-stroke fatigue - a multi-dimensional problem or a cluster of disorders? A case for phenotyping post-stroke fatigue

Post-stroke fatigue - a multi-dimensional problem or a cluster of disorders? A case for phenotyping post-stroke fatigue

The last decade has seen a considerable increase in scientific interest in poststroke fatigue resulting in studies addressing both the pathophysiology and therapeutic strategies for reduction of poststroke fatigue. Of the many emerging concepts, one that urgently needs to be addressed is identifying clusters/subtypes/phenotypes of poststroke fatigue. In this talk, I will present a case for three potential phenotypes, discuss evidence in support of the phenotypes and a proposal for multidimensional phenotyping as an essential step towards personalised interventions for post-stroke fatigue.

Anna Kuppuswamy graduated from Madras Medical College, India as a physiotherapist and obtained a masters from UCL and PhD from Imperial College London in Neuroscience. After a brief stint at the National Institutes of Health, USA in Prof Leo Cohen’s lab, she moved back to the UK to study post-stroke fatigue based at Institute of Neurology, Queen Square, UCL. In 2016 she started her lab with a Royal Society/Wellcome Trust Sir Henry Dale Fellowship. In 2020 she was appointed Principal Research Fellow at Institute of Neurology. Her principal research interests are investigating disease independent mechanisms of chronic pathological fatigue, primarily focusing on sensorimotor processing. Anna is currently a Principal Investigator at Leeds University and leads the NeuTraF lab.