Contact information
Research groups
Colleges
Sofia Toniolo
MD, MRCP (Neurology), DPhil, FEBN
Senior Research Fellow and Honorary Consultant Neurologist
- Cognitive Neurologist
- Fellow of the European Board of Neurology
- EAN Dementia and Cognitive Disorders Panel member
Digital Precision Metrics and Plasma biomarkers in Alzheimer's Disease
My research aim is to test whether by combining plasma biomarkers with digital precision cognitive metrics it is possible to develop more sensitive measures to detect Alzheimer's Disease (AD) early and track disease progression over time. I am also interested in using these tools to achieve more precise clinical stratification of subjects at risk of developing AD, such as patients with Subjective Cognitive Impairment (SCI) and Mild Cognitive Impairment (MCI). My work combines individual digital behavioural fingerprints, obtained though tablet or computer based assessments, and biological blood-derived markers of AD pathology. I also use neuroimaging to investigate the structural and functional correlates of these digital behavioural metrics in SCI, MCI and AD patients.
Recent publications
Transsaccadic working memory in healthy ageing and neurodegenerative disease.
Preprint
Zhao S. et al, (2026)
Remote digital cognitive assessment for aging and dementia using the Oxford Cognitive Testing Portal OCTAL.
Journal article
Zhao S. et al, (2026), NPJ Digit Med, 9
Dynamic updating of spatial working memory across eye movements: a computational investigation of transsaccadic integration
Preprint
Zhao S. et al, (2025)
Lower baseline serum neuronal-specific enolase levels predict better rate of recovery of functional walking ability in post-acute stroke patients.
Journal article
Brunelli S. et al, (2025), Neurol Sci, 47
Biomarkers
Journal article
Toniolo S. et al, (2025), Alzheimer S Dementia the Journal of the Alzheimer S Association, 21
