Contact information
+44 (0)1865 611497
Fax +44 (0)1865 222717
William Clarke
MR Spectroscopist
Advanced, open tools for MR Spectroscopy
I am currently looking for a research software engineer to join my lab to work on FSL-MRS. More information is available online. Applications can be made on the University Website, before 28th February 2025.
My work focusses on developing new methods for magnetic resonance spectroscopy (MRS). Using similar methods to MR imaging (MRI), MRS allows us to quantify the concentrations and chemical kinetics of many neurochemicals in the human brain. Furthermore, by using neurochemicals as endogenous probes we can also map cell-type-specific microstructure. My work seeks to develop new ways of acquiring multi-voxel spectroscopic information to measure chemical dynamics and cellular microstructure across the brain. I have released the open-science MRS analysis tool FSL-MRS and created a range of open-source tools for the MRS community. I am a cofounder of the educational website MRSHub.
In 2023 I started a spectroscopy group at WIN funded by a Wellcome Career Development Award. Previously I have worked as spectroscopist in the Physiological Neuroimaging Group and as a post-doctoral researcher in the UK7T Network. The UK7T Network brought together the five 7 tesla MRI capable sites in the UK to develop and promote scanning at this high field strength.
Prior to working in neuroimaging, I completed my doctorate in cardiovascular magnetic resonance spectroscopy. This work focused on the high-energy phosphorus metabolism of the human myocardium.
Key publications
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FSL‐MRS: An end‐to‐end spectroscopy analysis package
Clarke WT. et al, (2020), Magnetic Resonance in Medicine
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Creatine kinase rate constant in the human heart measured with 3D-localization at 7 tesla.
Clarke WT. et al, (2017), Magn Reson Med, 78, 20 - 32
Recent publications
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Feasibility and comparison of 3D modified rosette ultra-short echo time (PETALUTE) with conventional weighted acquisition in 31P-MRSI.
Bozymski B. et al, (2025), Sci Rep, 15
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Concentric Ring Trajectory Sampling With k-Space Reordering Enables Assessment of Tissue-Specific T1 and T2 Relaxation for 2H-Labeled Substrates in the Human Brain at 7 T.
Bader V. et al, (2025), NMR Biomed, 38
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Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations.
Rua C. et al, (2024), Brain
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Six-Week Supplementation with Creatine in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Magnetic Resonance Spectroscopy Feasibility Study at 3 Tesla.
Godlewska BR. et al, (2024), Nutrients, 16
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Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol.
Dean DC. et al, (2024), Dev Cogn Neurosci, 70