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Marco Samuel Fabuš


DPhil Student

Research Summary

My research interests are in systems-level mechanisms of the brain, especially as pertaining to anaesthesia and consciousness. I focus on analysis of non-invasive brain activity data collected during anaesthesia to understand how brains lose and regain perception of the external world.

Dr. Katie Warnaby, my supervisor, and her colleagues identified a marked change in brain activity under increasing doses of anaesthesia termed slow-wave saturation (SWAS). This pattern has been found present in volunteer data as well as data collected during routine surgical anaesthesia. Our group has recently been working on clinically translating this hypothesised marker of loss of perception by developing a novel depth of anaesthesia monitor utilising real-time slow-wave power calculation, validating it with a simultaneous EEG-fMRI study in volunteers as well a concurrent patient study. 

My DPhil builds on this work by utilising my own novel modelling tools and those recently developed in the Oxford Centre for Human Brain Activity (OHBA) under Prof. Mark Woolrich. We are especially interested in anaesthetic-dependent differences, neural inertia, and brain state transitions during anaesthesia. Understanding these will allow for better anaesthetic dosing and the potential to avoid postoperative problems such as delirium.

My background is in Physics where I obtained a Master's degree at St. John's College, Oxford, coming first in the year. My MPhys project under the supervision of Dr. Katie Warnaby and Prof. Myles Allen developed a new model of anaesthetic slow-wave power based on an analogy to a model of ferromagnetic hysteresis.