Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

OBJECTIVE: To assess the impact of electrode arrangement on the efficacy of tDCS in stroke survivors and determine whether changes in transcallosal inhibition (TCI) underlie improvements. METHODS: 24 stroke survivors (3-124months post-stroke) with upper limb impairment participated. They received blinded tDCS during a motor sequence learning task, requiring the paretic arm to direct a cursor to illuminating targets on a monitor. Four tDCS conditions were studied (crossover); anodal to ipsilesional M1, cathodal to contralesional M1, bihemispheric, sham. The Jebsen Taylor hand function test (JTT) was assessed pre- and post-stimulation and TCI assessed as the ipsilateral silent period (iSP) duration using transcranial magnetic stimulation. RESULTS: The time to react to target illumination reduced with learning of the movement sequence, irrespective of tDCS condition (p>0.1). JTT performance improved after unilateral tDCS (anodal or cathodal) compared with sham (p<0.05), but not after bihemispheric (p>0.1). There was no effect of tDCS on change in iSP duration (p>0.1). CONCLUSIONS: Unilateral tDCS is effective for improving JTT performance, but not motor sequence learning. SIGNIFICANCE: This has implications for the design of future clinical trials.

Original publication

DOI

10.1016/j.clinph.2017.03.036

Type

Journal article

Journal

Clin neurophysiol

Publication Date

07/2017

Volume

128

Pages

1389 - 1398

Keywords

Motor sequence learning, Stroke, Transcallosal inhibition, Transcranial direct current stimulation, Upper limb function, Adult, Aged, Cross-Over Studies, Electromyography, Evoked Potentials, Motor, Female, Follow-Up Studies, Humans, Learning, Male, Middle Aged, Motor Cortex, Photic Stimulation, Psychomotor Performance, Single-Blind Method, Stroke, Transcranial Direct Current Stimulation, Upper Extremity