A positive-negative mode of population covariation links brain connectivity, demographics and behavior.
Smith SM., Nichols TE., Vidaurre D., Winkler AM., Behrens TEJ., Glasser MF., Ugurbil K., Barch DM., Van Essen DC., Miller KL.
We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.