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PURPOSE: Increasing acquisition efficiency is always a challenge in high-resolution diffusion tensor imaging (DTI), which has low signal-to-noise ratio and is sensitive to reconstruction artifacts. In this study, a parallel imaging (PI) and compressed sensing (CS) combined framework is proposed, which features motion error correction, PI calibration, and sparsity model using inter-image correlation tailored for high-resolution DTI. THEORY AND METHODS: The proposed method, named anisotropic sparsity SPIRiT, consists of three steps: (i) motion-induced phase error estimation, (ii) initial CS reconstruction and PI kernel calibration, and (iii) final reconstruction combining PI and CS. Inter-image correlation of diffusion-weighted images are used through anisotropic signals for improved sparsity. A specific implementation based on multishot variable density spiral DTI is used to demonstrate the method. RESULTS: The proposed reconstruction method was compared with CG-SENSE, CS-based joint reconstruction, and PI and CS combined methods with L1 and joint sparsity regularization, in brain DTI experiments at acceleration factors of 3 to 5. Both qualitative and quantitative results demonstrated that the proposed method resulted in better preserved image quality and more accurate DTI parameters than other methods. CONCLUSION: The proposed method can accelerate high-resolution DTI acquisition effectively by using the sharable information among different diffusion encoding directions.

Original publication




Journal article


Magn Reson Med

Publication Date





1775 - 1785


anisotropic sparsity, compressed sensing, diffusion tensor imaging, parallel imaging, variable density spiral, Brain, Diffusion Magnetic Resonance Imaging, Humans, Image Enhancement, Image Processing, Computer-Assisted, Statistics as Topic