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Visual neglect after stroke is often associated with a failure to explore contralesional space. Here, we show that guanfacine, a noradrenergic agonist that modulates dorsolateral prefrontal cortex, improves leftward space exploration in selected right-hemisphere patients with neglect. The positive effects of guanfacine were associated with extended ability to maintain attention on task. The results suggest that neuropharmacological targeting of intact frontal areas might be one way to enhance cognitive function after damage to posterior brain regions in selected individuals.

Original publication




Journal article


Ann Neurol

Publication Date





186 - 190


Adrenergic alpha-Agonists, Animals, Attention, Guanfacine, Humans, Neuropsychological Tests, Norepinephrine, Perceptual Disorders, Space Perception, Stroke, Visual Perception