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BACKGROUND: A 44-year-old male presented to a general neurology clinic with a 6-month history of progressive right-sided spastic hemiparesis without sensory symptoms or signs. The thigh muscle in the affected leg showed signs of wasting. The patient had a remote family history of celiac disease. INVESTIGATIONS: Neurological examination, neurophysiological studies, brain MRI scan, routine blood tests, duodenal biopsy, cerebrospinal fluid analysis including polymerase chain reaction test for JC virus DNA, serological testing for HIV and for the presence of serum antibodies to endomysium, gliadin and tissue transglutaminase. DIAGNOSIS: Celiac disease with neurological involvement, mimicking amyotrophic lateral sclerosis. MANAGEMENT: Strict gluten-free diet.

Original publication

DOI

10.1038/ncpneuro0631

Type

Journal article

Journal

Nat Clin Pract Neurol

Publication Date

10/2007

Volume

3

Pages

581 - 584

Keywords

Adult, Amyotrophic Lateral Sclerosis, Brain, Celiac Disease, Diet, Protein-Restricted, Glutens, Humans, Magnetic Resonance Imaging, Male, Neurologic Examination, Sensitivity and Specificity, Serologic Tests