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Many hypotheses have been proposed about the brain underpinnings of developmental dyslexia, but none of them accommodates the variable deficits observed. To address the issue of anatomical deficits in dyslexia; total and partial volumes, lateralization indices (LI), and local gray matter volumes (LGMV) were measured. Analyses were performed in large samples of control and dyslexic subjects, and in correlation with their performance on phonological, reading, and spelling tests. Results indicate an absence of net differences in terms of volumes but significant continuities and discontinuities between groups in their correlations between LI, LGMV, and performances. Structural connectivity also highlighted correlations between areas showing (dis)continuities between control and dyslexic subjects. Overall, our data put forward the idea of a multifocal brain abnormalities in dyslexia with a major implication of the left superior temporal gyrus, occipital-temporal cortices, and lateral/medial cerebellum, which could account for the diverse deficits predicted by the different theories.

Original publication

DOI

10.1002/hbm.20670

Type

Journal article

Journal

Hum brain mapp

Publication Date

07/2009

Volume

30

Pages

2278 - 2292

Keywords

Adult, Analysis of Variance, Brain, Dyslexia, Female, Humans, Language Tests, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Organ Size, Phonetics, Reaction Time, Reading, Regression Analysis, Writing