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UK Biobank is a major prospective epidemiological study, including multimodal brain imaging, genetics and ongoing health outcomes. Previously, we published genome-wide associations of 3,144 brain imaging-derived phenotypes, with a discovery sample of 8,428 individuals. Here we present a new open resource of genome-wide association study summary statistics, using the 2020 data release, almost tripling the discovery sample size. We now include the X chromosome and new classes of imaging-derived phenotypes (subcortical volumes and tissue contrast). Previously, we found 148 replicated clusters of associations between genetic variants and imaging phenotypes; in this study, we found 692, including 12 on the X chromosome. We describe some of the newly found associations, focusing on the X chromosome and autosomal associations involving the new classes of imaging-derived phenotypes. Our novel associations implicate, for example, pathways involved in the rare X-linked STAR (syndactyly, telecanthus and anogenital and renal malformations) syndrome, Alzheimer's disease and mitochondrial disorders.

Original publication

DOI

10.1038/s41593-021-00826-4

Type

Journal article

Journal

Nat Neurosci

Publication Date

05/2021

Volume

24

Pages

737 - 745

Keywords

Biological Specimen Banks, Brain, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Humans, Magnetic Resonance Imaging, Phenotype, Polymorphism, Single Nucleotide, United Kingdom