Contact information
Research groups
Colleges
Sofia Toniolo
MD, MRCP (Neurology), DPhil, FEBN
Senior Research Fellow and Honorary Consultant Neurologist
- Cognitive Neurologist
- Fellow of the European Board of Neurology
- EAN Dementia and Cognitive Disorders Panel member
Digital Precision Metrics and Plasma biomarkers in Alzheimer's Disease
My research aim is to test whether by combining plasma biomarkers with digital precision cognitive metrics it is possible to develop more sensitive measures to detect Alzheimer's Disease (AD) early and track disease progression over time. I am also interested in using these tools to achieve more precise clinical stratification of subjects at risk of developing AD, such as patients with Subjective Cognitive Impairment (SCI) and Mild Cognitive Impairment (MCI). My work combines individual digital behavioural fingerprints, obtained though tablet or computer based assessments, and biological blood-derived markers of AD pathology. I also use neuroimaging to investigate the structural and functional correlates of these digital behavioural metrics in SCI, MCI and AD patients.
Recent publications
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Safety, tolerability, and efficacy outcomes of the Investigation of Levetiracetam in Alzheimer's disease (ILiAD) study: a pilot, double-blind placebo-controlled crossover trial.
Journal article
Sen A. et al, (2024), Epilepsia Open
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Perspectives on the diagnosis and management of functional cognitive disorder: An international Delphi study.
Journal article
Cabreira V. et al, (2024), Eur J Neurol
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Relationship of plasma biomarkers to digital cognitive tests in Alzheimer's disease.
Journal article
Toniolo S. et al, (2024), Alzheimers Dement (Amst), 16
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The role of the human hippocampus in decision-making under uncertainty
Journal article
Attaallah B. et al, (2024), Nature Human Behaviour
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Effects of COVID-19 on cognition and brain health.
Journal article
Zhao S. et al, (2023), Trends Cogn Sci