Rebeccah Slater is a Senior Wellcome Trust Research Fellow and Professor of Paediatric Neuroscience. She is also a Fellow of Green Templeton College.
Rebeccah studied Physics (BSc) at Imperial College and Neuroscience (MSc) at UCL, and in 2007 was awarded her PhD at UCL under the supervision of Prof Maria Fitzgerald. Since 2013 she has led the Paediatric Neuroimaging Research Group, which focuses on understanding the mechanisms that underlie the development of pain perception in the human infant. She uses a range of non-invasive brain imaging tools, including EEG and fMRI, to explore the development of pain perception in the human nervous system.
She has published many articles about infant pain and has been passionately involved in science communication and the public engagement of science. She has taken part in numerous discussions on TV and radio, including BBC Radio 4 and the BBC World Service. Rebeccah holds an honorary research position in the Neonatal Care Services at the John Radcliffe Children’s Hospital and is a PI at the Wellcome Centre for Integrative Neuroimaging (WIN).
Find out more about the Poppi Trial - a Randomised Controlled Trial investigating the analgesic efficacy of morphine in premature infants.
PhD MSc BSc ARSM
Professor of Paediatric Neuroscience
- Senior Wellcome Trust Research Fellow
Understanding the mechanisms that drive the development of pain perception in the human infant
Pain in infancy has negative long-term consequences and its prevention is a clinical priority, but adequate treatment requires mechanistic understanding of the structural and functional development of human nociceptive circuitry.
My research group aims to understand the mechanisms that drive and modulate pain perception in early human development. Recent scientific advances provide insights into how noxious information is transmitted to the infant brain, providing a platform to ask how intrinsic brain network connectivity and the environment affect noxious-evoked brain activity, behaviour and ultimately pain perception in the developing infant nervous system.
We are investigating whether inherent differences in how the brain behaves at rest influence variability in noxious-evoked activity, and will determine how this relationship is altered by environmental factors and pathology. We want to understand how the development of structural and functional network connectivity alters noxious-evoked brain activity, and influences the dynamic relationship between brain activity and behaviour.
The overarching goal is that this developmental understanding will translate into the improved treatment of infant pain in premature and term-born infants.
Hartley C. et al, (2020), Br J Anaesth
Eccleston C. et al, (2020), Lancet Child Adolesc Health
Slater R. et al, (2020), Lancet, 396, 872 - 873
Duff EP. et al, (2020), Lancet Digit Health, 2, e458 - e467
Inferring pain experience in infants using quantitative whole-brain functional MRI signatures: a cross-sectional, observational study
Duff EP. et al, (2020), LANCET DIGITAL HEALTH, 2, E458 - E467