Biography
Caroline is a Sir Henry Dale Fellow funded by the Wellcome Trust and Royal Society and is an Associate Professor.
Caroline completed her undergraduate degree in Mathematics at the University of Warwick in 2008. She then joined the Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, first undertaking a Master's degree in Mathematical Biology before carrying on to do a PhD. Her PhD research examined brain development in preterm babies, looking at EEG recordings and using computational neural network models to explore how neuronal connections form in the developing brain.
Caroline then moved to the University of Oxford, working as a Postdoctoral Researcher with Prof. Rebeccah Slater. As part of this work, Caroline developed methods to assess analgesic efficacy in infants using noxious-evoked brain activity, and led the Poppi (Procedural Pain in Premature Infants) Clinical Trial investigating the analgesic efficacy and safety of morphine in premature infants. In 2018, Caroline was awarded a Sir Henry Dale Fellowship to investigate the impact of apnoea on brain development in premature infants.
Caroline Hartley
MMath MRes PhD
Associate Professor & Wellcome Trust/Royal Society Sir Henry Dale Fellow
Caroline's research focuses on understanding the impact of apnoea on premature infant brain development. Apnoea - the cessation of breathing - is a common pathology associated with prematurity. These potentially life-threatening events can result in reduced cerebral oxygenation and frequent episodes of apnoea have been associated with long-term effects including reduced childhood cognitive ability. 1 in every 10 babies are born prematurely; understanding and mitigating the long-term impact of premature birth is important to improve the lives of these children. Caroline develops approaches to analyse infant brain activity and physiological data, such as heart rate and oxygen saturation, to address clinically relevant questions in the field of neonatal neuroscience.
Key publications
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Journal article
Hartley C. et al, (2018), Lancet, 392, 2595 - 2605
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Journal article
Hartley C. et al, (2017), Sci Transl Med, 9
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Journal article
Hartley C. et al, (2016), Curr Biol, 26, 1998 - 2002
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Journal article
Goksan S. et al, (2015), Elife, 4
Recent publications
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Journal article
Moschino L. et al, (2020), ERJ Open Res, 6
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Journal article
Hartley C. et al, (2020), PLoS One, 15
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Journal article
Hill RM. et al, (2019), Nat Commun, 10
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Journal article
Hill RM. et al, (2019), Nature communications, 10
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Setting up a stopping boundary for safety in a phase II trial: the Poppi trial
Conference paper
Bell JL. et al, (2019), TRIALS, 20