Benjamin Tendler
Sir Henry Wellcome Postdoctoral Fellow
My background is in physics, specialising in its application to the field of neuroscience. I am interested in developing new techniques to identify processes in brain disease using Magnetic Resonance Imaging (MRI). My fellowship aims to develop an imaging technique based on diffusion MRI, which produces images sensitive to the tiny motions of water in the brain. I will use my technique to see its potential in identifying brain markers of Parkinson's disease.
I will achieve this using a combination of post-mortem and in vivo imaging, based on a technique known as 'diffusion-weighted steady-state free precession'. More broadly, my research interests span diffusion MRI, susceptibility-based MRI and quantitative MRI, investigating how we can these methods to obtain more information about the composition and structure of the brain.
Over the past few years at Oxford, I have been focused on developing these techniques in the context of post-mortem brain imaging. For a brief explanation of this work, please see this video: https://youtu.be/-QUfZP4NOdg
To see how we are utilising post-mortem imaging in our research, and what datasets we have collected, please visit the Digital Brain Bank: https://open.win.ox.ac.uk/DigitalBrainBank/
Recent publications
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Why every lab needs a handbook.
Journal article
Tendler BC. et al, (2023), Elife, 12
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Both noise-floor and tissue compartment difference in diffusivity contribute to FA dependence on b-value in diffusion MRI.
Journal article
Yao J. et al, (2022), Hum Brain Mapp
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Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging.
Journal article
Wang C. et al, (2022), Nat Neurosci, 25, 818 - 831
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The Digital Brain Bank, an open access platform for post-mortem imaging datasets.
Journal article
Tendler BC. et al, (2022), Elife, 11
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Quantifying myelin in crossing fibers using diffusion-prepared phase imaging: Theory and simulations.
Journal article
Cottaar M. et al, (2021), Magn Reson Med, 86, 2618 - 2634