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Many stroke survivors experience poor sleep. We are testing whether an online sleep improvement programme may be effective for people who have had a stroke at least 3 months previously. 

Investigators: Melanie Fleming, Tom Smejka, Heidi Johansen-Berg

Collaborators: Colin Espie, Simon Kyle, Ramon Luengo-Fernandez, Heidi Johansen-Berg

Current Funders: Wellcome Trust, NIHR Oxford Biomedical Research Centre

Neurofeedback for stroke rehabilitation

Patterns of brain activity change after stroke. Neurofeedback aims to address impairment in brain activation through brain activation training. Neurofeedback involves displaying patterns of brain activity to a stroke survivor, in real time, while a task is being performed with the affected hand. By promoting beneficial brain activity patterns, this approach aims to extend or enhance the benefits of therapy. 

Investigators:  Melanie Fleming, Tom Smejka, Zeena Sanders, Cassandra Sampaio-Baptista, Heidi Johansen-Berg
Current Funders:  Wellcome Trust; NIHR Oxford Biomedical Research Centre


learning and sleep after brain injury

Motor learning is central to rehabilitation after brain injury. Sleep is important for consolidation of learning, but brain injury may affect sleep continuity. People who have had a stroke or brain injury commonly complain of tiredness, daytime sleepiness and increased need for sleep. We are aiming to assess the role of sleep quality on motor recovery in people receiving inpatient rehabilitation for stroke or brain injury and people in the community. 

Investigators:  Melanie Fleming, Tom Smejka, Heidi Johansen-Berg

Collaborators:  David Henderson Slater, Oxford University Hospitals NHS Foundation Trust

Current Funders:  Wellcome Trust; NIHR Biomedical Research Centre, Oxford

Selected publications

Neyedli HF, Sampaio-Baptista C, Kirkman MA, Havard D, Lührs M, Ramsden K, Flitney DD, Clare S, Goebel R & Johansen-Berg H (2018). Increasing lateralized motor activity in younger and older adults using Real-time fMRI during executed movements. Neuroscience, 378, 165–174.


Sampaio-Baptista C, Sanders Z-B & Johansen-Berg H (2018). Structural Plasticity in Adulthood with Motor Learning and Stroke Rehabilitation. Annual Review of Neuroscience, 41(1), annurev-neuro-080317-062015.

Gudberg C & Johansen-Berg H (2015). Sleep and Motor Learning: Implications for Physical Rehabilitation After Stroke. Frontiers in Neurology, 6.

Stagg CJ, Bachtiar V, OShea J, Allman C, Bosnell RA, Kischka U, Matthews PM, Johansen-Berg H (2012). Cortical activation changes underlying stimulation-induced behavioural gains in chronic stroke. Brain 135(Pt 1):276-84.

O'Shea J, Boudrias MH, Stagg CJ, Bachtiar V, Kischka U, Blicher JU, Johansen-Berg H (2014). Predicting behavioural response to TDCS in chronic motor stroke. Neuroimage 85 Pt 3:924-33.

Stagg CJ, Best J, Stephenson, M, O'Shea J, Wylezinska M, Kincses Z, Morris P, Matthews PM, and Johansen-Berg, H (2009). Polarity-sensitive modulation of cortical neurotransmitters by transcranial stimulation J Neurosci 29(16):5202-5206.

Crofts JJ, Higham DJ, Bosnell R, Jbabdi S, Matthews PM, Behrens TE, and Johansen-Berg H (2011). Network analysis detects changes in the contralesional hemisphere following stroke Neuroimage 54(1):161-169.

Dennis A, Bosnell R, Dawes H, Howells K, Cockburn J, Kischka U, Matthews P, and Johansen-Berg H (2011). Cognitive context determines dorsal premotor cortical activity during hand movement in patients after stroke Stroke 42(4):1056-1061.

Johansen-Berg H, Dawes H, Guy C, Smith SM, Wade DT, and Matthews PM (2002). Correlation between motor improvements and altered fMRI activity after rehabilitative therapy. Brain 125(Pt 12):2731-42.

Johansen-Berg H, Rushworth MF, Bogdanovic MD, Kischka U, Wimalaratna S, and Matthews PM (2002). The role of ipsilateral premotor cortex in hand movement after stroke. Proc Natl Acad Sci USA 99(22):14518-23.