Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.
Skip to main content

The PI3K signalling pathway is crucial to normal B cell development and response to antigen. The p1108 catalytic subunit plays an important and non-redundant role within this pathway although other catalytic isoforms may also contribute. Although CD40, TLR and cytokines all activate PI3K the BCR seems especially dependent upon PI3K signalling. The downstream effects of PI3K may be mediated to a large extent by activation of PKB. In B cell development PI3K promotes development of MZ and Bl cells. In the response to antigen PI3K is crucial to BCR-mediated proliferation. PI3K activity has been shown to be inhibitory to CSR. The effects on immunoglobulin production and ASC differentiation are harder to disentangle from the developmental effects on cell populations and at present remain uncertain.

Type

Conference paper

Publication Date

2009

Volume

633

Pages

43 - 53

Keywords

Animals, Antigens, B-Lymphocytes, Humans, Phosphatidylinositol 3-Kinases, Signal Transduction