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The aim of this study was to assess the usefulness of proton MR spectroscopy in the diagnosis of intraventricular tumours. Fifty-two intraventricular tumours pertaining to 16 different tumour types were derived from our database. All cases had single-voxel proton MR spectroscopy performed at TE at both 30 and 136 ms at 1.5 T. The Mann-Whitney U test was used to search for the most discriminative datapoints each tumour type. Characteristic trends were found for some groups: high Glx and Ala in meningiomas (p < 0.001 and p < 0.01, respectively), high mobile lipids in metastasis (p < 0.001), high Cho in PNET (p < 0.001), high mI + Gly in ependymoma (p < 0.001), high NAC (p < 0.01) in the absence of the normal brain parenchyma pattern in colloid cysts, and high mI/Gly and Ala in central neurocytoma. Proton MR spectroscopy provides additional metabolic information that could be useful in the diagnosis of intraventricular brain tumors.

Original publication

DOI

10.1007/s00330-009-1357-y

Type

Journal article

Journal

Eur Radiol

Publication Date

08/2009

Volume

19

Pages

2049 - 2059

Keywords

Adolescent, Adult, Aged, Biomarkers, Tumor, Brain, Cerebral Ventricle Neoplasms, Female, Humans, Male, Middle Aged, Protons, Reproducibility of Results, Sensitivity and Specificity, Young Adult