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A 30 base synthetic oligonucleotide probe was used to detect the mRNA encoding the rat D2 dopaminergic receptor. On Northern analysis, the probe identified a single species of mRNA of approximately 2.9 kb, present at highest levels in the striatum but also found in the brainstem, neocortex and diencephalon. On sections, neurons containing high levels of the mRNA were detected in the striatum, the substantia nigra pars compacta and the ventral tegmental area. Lower levels of signal were seen over neurons in the hypothalamus, the frontal neocortex, and the globus pallidus.

Type

Journal article

Journal

Febs lett

Publication Date

25/09/1989

Volume

255

Pages

335 - 339

Keywords

Animals, Autoradiography, Blotting, Northern, Brain, Histocytochemistry, Male, Nucleic Acid Hybridization, Oligonucleotide Probes, Organ Specificity, Phosphorus Radioisotopes, RNA, Messenger, Rats, Rats, Inbred Strains, Receptors, Dopamine, Receptors, Dopamine D2, Sulfur Radioisotopes