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<jats:p>Testosterone enhances amygdala reactions to social threat, but it remains unclear whether this neuroendocrine mechanism is relevant for understanding its dominance-enhancing properties; namely, whether testosterone biases the human amygdala toward threat approach. This pharmacological functional magnetic-resonance imaging study shows that testosterone administration increases amygdala responses in healthy women during threat approach and decreases it during threat avoidance. These findings support and extend motivational salience models by offering a neuroendocrine mechanism of motivation-specific amygdala tuning.</jats:p>

Original publication

DOI

10.1126/sciadv.1400074

Type

Journal article

Journal

Science Advances

Publisher

American Association for the Advancement of Science (AAAS)

Publication Date

06/2015

Volume

1

Pages

e1400074 - e1400074