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Myelin is important for the normal development and healthy function of the nervous system. Recent developments in MRI acquisition and tissue modeling aim to provide a better characterization and more specific markers for myelin. This allows for specific monitoring of myelination longitudinally and noninvasively in the healthy brain as well as assessment of treatment and intervention efficacy. Here, we offer a nontechnical review of MRI techniques developed to specifically monitor myelin such as magnetization transfer (MT) and myelin water imaging (MWI). We further summarize recent studies that employ these methods to measure myelin in relation to development and aging, learning and experience, and neuropathology and psychiatric disorders. © 2017 Wiley Periodicals, Inc. Develop Neurobiol, 2017.

Original publication

DOI

10.1002/dneu.22552

Type

Journal article

Journal

Dev Neurobiol

Publication Date

30/10/2017

Keywords

MRI, Myelin, magnetization transfer, myelin water imaging