Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism.

Chong TT-J., Bonnelle V., Veromann K-R., Juurmaa J., Taba P., Plant O., Husain M.

Methcathinone-induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost-benefit decision-making task, in which participants decided whether it was worth investing effort for reward. Patients showed a dissociation between reward and effort sensitivity, such that pallidonigral complex dysfunction caused them to become less sensitive to rewards, while normal sensitivity to effort costs was maintained.

DOI

10.1111/jnp.12122

Type

Journal article

Journal

J Neuropsychol

Publication Date

06/2018

Volume

12

Pages

291 - 297

Keywords

Parkinsonism, effort, methcathinone, motivation, reward

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