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We studied the effects of temazepam premedication and induction of anaesthesia with thiopentone or propofol on the heart rate power spectrum in 47 patients undergoing elective minor surgery. Eighteen patients received temazepam 20 mg orally as premedication. There was a significant reduction in high frequency power and total power, and an increase in the ratio of low to high frequency power after induction of anaesthesia with either propofol or thiopentone. Patients who had received temazepam premedication had significantly greater low frequency, high frequency and total power than those who were not premedicated. There was no significant difference between premedicated and unpremedicated patients in the ratio of low to ventilatory frequency power.

Original publication




Journal article


Br J Anaesth

Publication Date





168 - 173


Adult, Aged, Electrocardiography, Female, Fourier Analysis, Heart Rate, Humans, Male, Middle Aged, Plethysmography, Impedance, Preanesthetic Medication, Propofol, Respiration, Temazepam, Thiopental