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The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research.

Original publication




Journal article


PLoS Comput Biol

Publication Date





Adult, Animals, Anisotropy, Brain, Brain Mapping, Cluster Analysis, Connectome, Diffusion, Diffusion Magnetic Resonance Imaging, Female, Humans, Macaca, Male, Nerve Net, Neural Pathways, Species Specificity