Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The measurement of brain metabolism in vivo has been a major challenge in neuroscience research, and it is only in recent years with the advent of magnetic resonance spectroscopy (MRS) methods that this has become possible. In this chapter, we discuss how 13 C MRS in combination with 13 C isotopically labeled substrates can be used to quantitatively measure the major pathways of brain energy metabolism and function, and how this can be exploited to gain insight into metabolic compartmentation and neuron-astrocyte interactions. Furthermore, we discuss the advances in our understanding of the relationship between glucose metabolism and neuronal function that these approaches have enabled. We also briefly discuss alternatives to direct 13 C MRS using indirect 13 C detection through coupled protons ( 1 H-[ 13 C] MRS) and 15 N MRS. We will discuss both initial work in animals in which the use of MRS methods for measurement of neuroenergetics and neurotransmission were validated, and also their more recent translation to humans. © 2014 Elsevier Inc. All rights reserved.

Original publication

DOI

10.1016/B978-0-12-401688-0.00021-5

Type

Chapter

Book title

Magnetic Resonance Spectroscopy: Tools for Neuroscience Research and Emerging Clinical Applications

Publication Date

01/12/2013

Pages

274 - 288