Leginon: a system for fully automated acquisition of 1000 electron micrographs a day.
Potter CS., Chu H., Frey B., Green C., Kisseberth N., Madden TJ., Miller KL., Nahrstedt K., Pulokas J., Reilein A., Tcheng D., Weber D., Carragher B.
We have developed a system to automatically acquire large numbers of acceptable quality images from specimens of negatively stained catalase, a biological protein which forms crystals. In this paper we will describe the details of the system architecture and analyze the performance of the system as compared to a human operator. The ultimate goal of the system if to automate the process of acquiring cryo-electron micrographs.