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Bupropion is not licensed as an antidepressant in the UK, limiting its use. We highlight bupropion's distinct pharmacological profile and its potential benefits in treatment-resistant depression and people experiencing selective serotonin reuptake inhibitor-induced sexual dysfunction. The National Health Service repurposing medicines programme could improve equity of access for UK patients.

Original publication

DOI

10.1192/bjp.2025.50

Type

Journal

Br J Psychiatry

Publication Date

03/04/2025

Pages

1 - 3

Keywords

Bupropion, depression, inflammation, licensing, sexual dysfunction