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The human orbitofrontal cortex is strongly implicated in appetitive valuation. Whether its role extends to support comparative valuation necessary to explain probabilistic choice patterns for incommensurable goods is unknown. Using a binary choice paradigm, we derived the subjective values of different bundles of goods, under conditions of both gain and loss. We demonstrate that orbitofrontal activation reflects the difference in subjective value between available options, an effect evident across valuation for both gains and losses. In contrast, activation in dorsal striatum and supplementary motor areas reflects subjects' choice probabilities. These findings indicate that orbitofrontal cortex plays a pivotal role in valuation for incommensurable goods, a critical component process in human decision making. Copyright © 2009 Society for Neuroscience.

Original publication

DOI

10.1523/JNEUROSCI.0717-09.2009

Type

Journal article

Journal

Journal of Neuroscience

Publication Date

01/07/2009

Volume

29

Pages

8388 - 8395