Prof Turner has regular DPhil opportunities for both clinically- and non-clinically-qualified candidates and informal contact to discuss options is welcomed. There is flexibility to develop ideas and interests within a broad theme of biomarker development in ALS and FTD, and clinically-qualified candidates would also receive training in neurodegenerative disorders and their management. Projects can be focused on large-scale neural network structure and functional studies using advanced neuroimaging (MRI) and neurophysiology (e.g. MEG) based in WIN , or biochemical assay development in human biofluid samples applying techniques such as proteomics and extracellular vesicle extraction through our collaborators. Post mortem ALS tissue ultra-high resolution MRI and histopathology integration is another theme, in collaboration with Prof Karla Miller and Dr Olaf Ansorge.
MA (Cantab) MBBS PhD FRCP (Lond)
Professor of Clinical Neurology & Neuroscience
- Consultant Neurologist, John Radcliffe Hospital
Motor system imaging and biochemical biomarker development in amyotrophic lateral sclerosis
My group's research involves patients diagnosed with motor neurone disease (MND), known in its commonest form as amyotrophic lateral sclerosis (ALS).
MND is a progressive neurodegenerative disease that dramatically shortens the lives of the majority of those who develop it because there is no effective disease-modifying treatment as yet. It causes relentless weakness in the limbs and often speech and swallowing muscles, with loss of independence and eventual respiratory failure. Those who develop MND have typically led healthy, active lives, and only a minority have a family history of the disease or the related condition frontotemporal dementia (FTD).
My group is trying to identify markers of disease activity across the different types of MND. These are called biomarkers. There is no test for MND, so diagnosis relies on the opinion of an expert neurologist, and any investigations are currently only to exclude other possible causes for the same symptoms (of which there are not many). Biomarkers might be able to shorten the delay of up to one year that many patients with MND have to wait to get a firm diagnosis. This might allow potential therapies to be introduced earlier, before there is spread of symptoms to more than one body region. It would also allow drug trials to be organised more efficiently, by categorizing patients according to disease activity, and making decisions about efficacy much sooner.
The Oxford Study for Biomarkers in MND ('BioMOx') is a platform for studying MND patient volunteers (of all different sub-types) who have agreed to undergo advanced magnetic resonance imaging (MRI) and magnetoencephalographic (MEG) studies of the brain along with spinal fluid and blood samples, to define potential biomarkers. We are also keen to study healthy volunteers and individuals with conditions that look similar to MND for comparison.
BioMOx has already identified a series of potential changes in the brains of MND patients that might be able to serve as biomarkers when combined together, and with substances identified in the blood and spinal fluid samples.
A new initiative: Families for the Treatment of Hereditary MND, FaTHoM, includes the study of rare individuals from families where members of successive generations develop MND, or sometimes FTD. This will allow us to identify the very earliest changes, and ways to intervene and prevent MND and FTD, with the aim of translating these findings to those already living with the disease.
Find out more at: www.biomox.net
Aside from my research, as a consultant neurologist at the John Radcliffe Hospital I see patients with a range of other neurological diseases in my outpatient clinic, and contribute to the acute out-of-hours service. I chair the Association of British Neurologists Research Committee with oversight of their flagship Clinical Research Training Fellowship scheme. I am Senior Research Fellow at Green Templeton College, and undertake regular teaching of Oxford University medical students, as well as educating junior doctors and regional GPs about all aspects of neurological disease.
Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T applied to amyotrophic lateral sclerosis.
Wang C. et al, (2020), Neuroimage
Quantitative patterns of motor cortex proteinopathy across ALS genotypes.
Nolan M. et al, (2020), Acta Neuropathol Commun, 8
Reply to: Early white matter changes on diffusion tensor imaging in amyotrophic lateral sclerosis.
Gabel MC. et al, (2020), Ann Clin Transl Neurol, 7, 1266 - 1267
Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study.
Varatharaj A. et al, (2020), Lancet Psychiatry
Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair.
Ababneh NA. et al, (2020), Hum Mol Genet