Jason Lerch
Professor of Neuroscience
I am the director of Preclinical Imaging at the Wellcome Centre for Integrative Neuroimaging (WIN) at the University of Oxford (and retain my affiliations in Canada as an adjunct scientist at the Mouse Imaging Centre (MICe) of the Hospital for Sick Children and an associate professor in medical biophysics at the University of Toronto).
My primary research interests are:
- parsing autism and related neurodevelopmental conditions
- understanding how sex and gender shape the brain and how that drives sex disparities in multiple mental health conditions
- figuring out the bases of MRI detectable brain plasticity
Underlying these research interests is a keen desire to improve our acquisition, processing, and analysis methods. This relates in particular to how we can combine mechanistic experiments in model species, in particular the mouse, with human patient and population studies.
DPHIL projects
I have regular DPhil opportunities for candidates with a background in neuroscience, engineering, computer science, or physics. Projects will usually be designed collaboratively with the candidate. Please get in touch if you would like to discuss possible projects, including an up-to-date CV.
Key publications
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Whole-brain comparison of rodent and human brains using spatial transcriptomics.
Journal article
Beauchamp A. et al, (2022), Elife, 11
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Examining overlap and homogeneity in ASD, ADHD, and OCD: a data-driven, diagnosis-agnostic approach.
Journal article
Kushki A. et al, (2019), Transl Psychiatry, 9
Recent publications
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A cross-species analysis of neuroanatomical covariance sex differences in humans and mice.
Journal article
Pham L. et al, (2025), Biol Sex Differ, 16
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Subgrouping autism and ADHD based on structural MRI population modelling centiles.
Journal article
Pecci-Terroba C. et al, (2025), Mol Autism, 16
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In Vivo Quantification of Creatine Kinase Kinetics in Mouse Brain Using 31P-MRS at 7 T
Journal article
Tachrount M. et al, (2025), NMR in Biomedicine, 38
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Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice.
Journal article
Pantiru AD. et al, (2025), Mol Autism, 16
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Probing Autism and ADHD subtypes using cortical signatures of the T1w/T2w-ratio and morphometry.
Journal article
Norbom LB. et al, (2025), Neuroimage Clin, 45
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