Jason Lerch
Professor of Neuroscience
I am the director of Preclinical Imaging at the Wellcome Centre for Integrative Neuroimaging (WIN) at the University of Oxford (and retain my affiliations in Canada as an adjunct scientist at the Mouse Imaging Centre (MICe) of the Hospital for Sick Children and an associate professor in medical biophysics at the University of Toronto).
My primary research interests are:
- parsing autism and related neurodevelopmental conditions
- understanding how sex and gender shape the brain and how that drives sex disparities in multiple mental health conditions
- figuring out the bases of MRI detectable brain plasticity
Underlying these research interests is a keen desire to improve our acquisition, processing, and analysis methods. This relates in particular to how we can combine mechanistic experiments in model species, in particular the mouse, with human patient and population studies.
DPHIL projects
I have regular DPhil opportunities for candidates with a background in neuroscience, engineering, computer science, or physics. Projects will usually be designed collaboratively with the candidate. Please get in touch if you would like to discuss possible projects, including an up-to-date CV.
Key publications
Whole-brain comparison of rodent and human brains using spatial transcriptomics.
Journal article
Beauchamp A. et al, (2022), Elife, 11
Examining overlap and homogeneity in ASD, ADHD, and OCD: a data-driven, diagnosis-agnostic approach.
Journal article
Kushki A. et al, (2019), Transl Psychiatry, 9
Mouse MRI shows brain areas relatively larger in males emerge before those larger in females.
Journal article
Qiu LR. et al, (2018), Nat Commun, 9
Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity.
Journal article
Ellegood J. et al, (2015), Mol Psychiatry, 20, 118 - 125
Maze training in mice induces MRI-detectable brain shape changes specific to the type of learning.
Journal article
Lerch JP. et al, (2011), Neuroimage, 54, 2086 - 2095
Recent publications
Macrostructural, microstructural, and cellular effects of neuroinflammation on the mouse brain.
Journal article
Patel Y. et al, (2026), Brain Behav Immun Health, 52
Altered Brain Structure in an ATRX-Deficient Mouse Model of Autism Spectrum Disorder.
Journal article
Quesnel K. et al, (2026), Autism Res
Enrichment-induced forgetting is associated with white matter microstructure in mice.
Journal article
Gazdzinski LM. et al, (2026), Behav Brain Res, 497
Probing the Influence of Paternal Diet on Offspring Neuroanatomy With Mouse MRI.
Journal article
McKnight EGW. et al, (2026), Brain Behav, 16
Research team
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Antoine Cherix
Research Associate in Preclinical Neuroimaging
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Alberto Lazari
Research Fellow
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Clemence Ligneul
Researcher (Visiting Academic)
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Sean Smart
Senior Research Associate
