James Larkin
MBiochem, PhD, FHEA
Senior postdoctoral researcher
Research Summary
My research spans the diagnosis and characterisation of tumours, primarily brain metastases.
For diagnosis, I use metabolomics. This is a technique that uses NMR to analyse biofluids, such as urine and blood plasma. NMR is followed by multivariate statistical analyses which are used to build classification models capable of separating cohorts from each other – an example would be the separation of patients with and without brain metastases.
For characterisation, I use advanced MRI techniques to image brain tumours non-invasively. I'm particularly interested in functional imaging, such as blood flow, and using these images to more accurately define true tumour extent in the brain.
BIOGRAPHY
James' first degree was in Biochemistry at the University of Oxford which he followed with work at the Sanger Institute in Cambridge and the University of Essex. He completed his PhD at Warwick University before moving back to Oxford to begin work in the Department of Oncology. In addition to his research, he is a Lecturer in Biochemistry at Trinity College, focussing on molecular cell biology.
Recent publications
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Data from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms
Other
Larkin JR. et al, (2023)
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Data from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms
Other
Larkin JR. et al, (2023)
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Data from STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction
Other
Sarmiento Soto M. et al, (2023)
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Data from STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction
Other
Sarmiento Soto M. et al, (2023)
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Data from Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging
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Ray KJ. et al, (2023)
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Data from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface
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Cheng VWT. et al, (2023)
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Data from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface
Other
Cheng VWT. et al, (2023)
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Figure S1 from STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction
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Sarmiento Soto M. et al, (2023)
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Figure S1 from STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction
Other
Sarmiento Soto M. et al, (2023)
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Figure S2 from STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction
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Sarmiento Soto M. et al, (2023)