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MorrisMotivation in depression: Can high-field MRI, neurofeedback and real-world digital phenotyping provide novel insights into psychiatric syndromes?  

Abstract: Motivational states are driven by environmental and internal reinforcers with their own reward values that can be perturbed in individuals with anhedonic depression. Although preclinical research implicates the dopamine system in modulating motivation/anhedonia, translation of these findings to humans remains limited by traditional neuroimaging and behavioural measures. This project will extend my prior work in developing ultra-high-field MRI sequences and novel cognitive/computational methods to not only measure but also directly modulate neural activity in dopaminergic circuits in individuals with depression. 


Dr. Laurel S. Morris is an Associate Professor in the Department of Psychiatry at the Icahn School of Medicine at Mount Sinai. She leads the Cognitive and High-resolution Imaging in Psychiatry (CHIP) lab at Mount Sinai. The lab seeks to develop neurocognitive assessments for in-depth characterizations of cognitive function in a range of neuropsychiatric disorders, and to optimize high-field 7-Tesla MRI protocols to examine small brain structures. Dr. Morris also leads the Neuroimaging Core and the Digital Phenotyping Core at the Depression and Anxiety Center for Discovery and Treatment at Mount Sinai.