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WIN Wednesday Works In ProgressSTEP-ENHANCE - AugmENtation witH cAnnabidiol iN first episode psyChosis: a doublE blind randomised controlled trial

Presented by George Gifford

Abstract: Despite the fact that antipsychotics are effective in most people with schizophrenia, about a third of patients respond poorly. There is evidence that non-response to antipsychotic treatment may be associated with neurobiological alterations other than D2 dysregulation, suggesting non-dopaminergic pharmacological treatments may be helpful. The first trials investigating the effects of cannabidiol (CBD) on psychotic symptoms in schizophrenia have reported positive results, however these studies investigated chronic psychosis. STEP-ENHACE is a multisite prospective randomised control trials of CBD in a cohort of First Episode Psychosis participants. The study aims to investigate whether the response to antipsychotic treatment can be enhanced by adding cannabidiol (CBD)to the existing treatment, compared to placebo, in participants with a first episode of psychosis, who have had a suboptimal or no response to their first antipsychotic treatment. Participants will be administered MRI at baseline and follow up, including structural MRI, resting state fMRI, MRS, and neuromelanin sensitive MRI.

 

WIN Ambassador Schemes

We're excited to announce the launch of our new EDI Ambassador Scheme, which will be running in 2025 alongside our annual Public Engagement and Open Science Ambassador Schemes. These schemes are open to all WIN members at any career stage, and provide a wonderful opportunity to build skills and play an active role in the PE, EDI or Open Science communities at WIN. Selected participants receive training, support and access to resources to develop projects and bring their ideas to life. Applications for all three schemes will open in November. In this session, representatives of each scheme will present the goals and structure of the programme and explain how you can get involved.