Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Developing an in vivo microscope for brain structure and function using diffusion MRI

Jelescu IleanaThere is currently no microscopy technique that qualifies as in vivo and non-invasive… or is there? It had been a long winding road, but diffusion MRI combined with biophysical modelling may just fill that role. In this talk, we will (i) go through the latest developments and validation steps of relevant models for quantifying white and gray matter microstructure, (ii) cover their recent applications to a range of diseases, highlighting the added value of diffusion-derived microstructure metrics to disentangle pathological events and trajectories, and (iii) take a fresh look at the potential of diffusion functional MRI to detect brain activity, as an alternative to conventional contrasts that rely on neurovascular coupling.